Bipolar Disorder A Concise Review - 3296 Words

Molecular Mechanisms implicated in Bipolar Disorder: A concise Review Neurobiology of Bipolar Disorder: A concise Review Mutahar Andrabia, Muatar Maknoon Andrabi, Remesh Kunjunnia, Sandeep Sathianathana, Mukesh Kumar Sriwastvaa, Rajesh Sagarb, Rashmi Mathurc, Vivekanandhan Subbiaha* a Deptt. Of Neurobiochemistry, All India Institute of Medical Sciences, India, New Delhi-29 b Deptt. Of Psychiatry, All India Institute of Medical Sciences, India, New Delhi-29 c Deptt. Of Physiology, All India Institute of Medical Sciences, India, New Delhi-29 †¢ Mutahar Andrabi (PhD student, Neuro Biochemistry) Email: mutahar.andrabi@gmail.com †¢ Remesh Kunjunni (PhD student, Neuro Biochemistry) Email: remeshmarangad@gmail.com †¢ Sandeep Sathianathan (PhD student, Neuro Biochemistry) Email: mailstosandeep@gmail.com †¢ Mukesh Kumar Sriwastva (PhD student, Neuro Biochemistry) Email: sriwastva.mukesh6@gmail.com †¢ Rajesh Sagar (MD) Email: rsagar29@gmail.com †¢ Rashmi Mathur Email: mathurashmi@yahoo.co.in †¢ Corresponding Author* Vivekanandhan Subbiah, PhD Email: svivek_aiims@yahoo.com (Corresponding Author) Key words: Bipolar Disorder, epinephrine, serotonin, dopamine, circadian system, BDNF. Bipolar disorder is a serious and devastating mental disorder. Suicidal ideation and comorbid conditions further worsen the outcome and prognosis. Abnormalities in monoaminergic pathways and signaling networks have been shown to be involved in the pathogenesis of disorder. 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